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Article

Activated protein C resistance: molecular mechanisms.

Thrombosis and haemostasis - 1 Jul 1995

Griffin J H, Heeb M J, Kojima Y, Fernández J A, Kojima K, Hackeng T M, Greengard J S

Abstract excerpt

Activated protein C (APC) resistance is usually associated with a single DNA mutation predicting replacement of Arg506 by Gln in factor V (FV). Studies using synthetic peptides suggest that FV residues 493-506 provide factor Xa (FXa) and protein S binding sites. Biochemical studies were performed to test the hypothesis that the Arg506Gln FV mutation causes APC resistance and to define the nature of the resistance...

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Source

Identifiers

PMID: 8578503

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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