Article
Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Mustafa A, Lannfelt L, Lilius L, Islam A, Winblad B, Adem A
Abstract excerpt
The plasma insulin-like growth factor I (IGF-I) level was determined in family members carrying the Swedish amyloid precursor protein (APP) 670/671 mutation with or without Alzheimer's disease (AD) and in age-matched controls from the same family. Plasma growth hormone (GH) and prolactin (PRL) levels were also determined. Measurement of the plasma IGF-I level by radioimmunoassay revealed a significant reduction...
Topics
- Aged
- Aging
- Alzheimer Disease
- Female
- Heterozygote
- Human Growth Hormone
- Humans
- Insulin-Like Growth Factor I
- Male
- Middle Aged
- Mutation