Article
Low cerebrospinal-fluid concentrations of soluble amyloid beta-protein precursor in hereditary Alzheimer's disease.
Lancet (London, England) - 22 Aug 1992
Farlow M, Ghetti B, Benson M D, Farrow J S, van Nostrand W E, Wagner S L
Abstract excerpt
In Alzheimer's disease, deposits of amyloid beta-protein are apparently derived from intracellular processing of a large precursor protein. We have measured concentrations of this precursor in cerebrospinal fluid (CSF) from six members of a family affected by presenile Alzheimer's disease associated with a point mutation of the precursor gene. One gene carrier with clinical signs of the disorder had low CSF...
Topics
- Adult
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Heterozygote
- Humans
- Immunoblotting
- Middle Aged
- Mutation
- Neuropsychological Tests
- Pedigree
- Polymerase Chain Reaction