Article
Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.
Biochemical and biophysical research communications - 5 Jan 1996
Essalmani R, Macq A F, Mercken L, Octave J N
Abstract excerpt
Production of soluble amyloid peptide precursor (APP) and amyloid peptide (A beta) was measured in CHO cells transfected by the wild-type APP 695 cDNA sequence or by the same sequence carrying missense mutations associated with familial Alzheimer's disease in Sweden. Deletion of the C-terminal do...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA Primers
- Gene Expression
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Processing, Post-Translational
- Recombinant Proteins
- Restriction Mapping
- Sequence Deletion