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Article

Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants.

The American journal of physiology - 1 Dec 1995

Ward S M, Burns A J, Torihashi S, Harney S C, Sanders K M

Abstract excerpt

Electrical rhythmicity in the gastrointestinal tract may originate in interstitial cells of Cajal (IC). Development of IC in the small intestine is linked to signaling via the tyrosine kinase receptor, c-kit. IC express c-kit protein, and disruption of c-kit signaling causes breakdown in IC netwo...

Topics

Animals
Animals, Newborn
Chromosome Mapping
Intestine, Small
Mice
Mice, Inbred Strains
Microscopy, Electron
Mutation
Myenteric Plexus
Myoelectric Complex, Migrating
Proto-Oncogene Proteins c-kit
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stem Cell Factor

Source

Identifiers

PMID: 8572188
DOI: 10.1152/ajpcell.1995.269.6.C1577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8572188-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants.PMID 8572188Read ↗

Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.Semantic proximity Read ↗

Disorders of Interstitial Cells of CajalSemantic proximity Read ↗

Development and plasticity of interstitial cells of CajalSemantic proximity Read ↗

Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks.Semantic proximity Read ↗

Kit mutants and gastrointestinal physiology.Semantic proximity Read ↗

W(sh)/W(sh) c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine.Semantic proximity Read ↗

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IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of CajalSemantic proximity Read ↗

Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine.Semantic proximity Read ↗

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