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Article

Functional substitution identifies a cell survival promoting domain common to adenovirus E1B 19 kDa and Bcl-2 proteins.

Oncogene - 7 Dec 1995

Subramanian T, Boyd J M, Chinnadurai G

Abstract excerpt

The adenovirus E1B 19 kDa protein provides a cell survival function during adenovirus infection and facilitates efficient virus replication by preventing premature cell death. These functions resemble those performed by the protein coded by the proto-oncogene Bcl-1. The Bcl-1 protein, which provi...

Topics

Adenovirus E1B Proteins
Amino Acid Sequence
Animals
Cell Line
Cell Survival
Cloning, Molecular
Molecular Sequence Data
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Rats
Rats, Inbred F344

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

bcl-2-Associated X Protein

Source

Identifiers

PMID: 8570192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8570192-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Functional substitution identifies a cell survival promoting domain common to adenovirus E1B 19 kDa and Bcl-2 proteins.PMID 8570192Read ↗

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteinsSemantic proximity Read ↗

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cellsSemantic proximity Read ↗

Functional similarity between adenovirus E1B 19-kDa protein and proteins encoded by Bcl-2 proto-oncogene and Epstein-Barr virus BHRF1 gene.Semantic proximity Read ↗

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.Semantic proximity Read ↗

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19KSemantic proximity Read ↗

The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis.Semantic proximity Read ↗

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisSemantic proximity Read ↗

BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates.Semantic proximity Read ↗

Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest.Semantic proximity Read ↗

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.Semantic proximity Read ↗

Overexpression of the E1B 55-kilodalton (482R) protein of human adenovirus type 12 appears to permit efficient transformation of primary baby rat kidney cells in the absence of the E1B 19-kilodalton protein.Semantic proximity Read ↗

Requirement of BAX for efficient adenovirus-induced apoptosis.Semantic proximity Read ↗

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