Article
The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis.
Oncogene - 25 Sept 1997
Rao L, Modha D, White E
Abstract excerpt
Expression of the E1B 19K protein is required to inhibit apoptosis induced by E1A during adenovirus infection and transformation. E1B 19K is homologous to Bcl-2 in function and the two proteins also share limited amino acid sequence homology. Consequently, the E1B 19K and Bcl-2 proteins bind to a...
Topics
- Adenovirus E1B Proteins
- Apoptosis
- Cell Line, Transformed
- Lamin Type A
- Lamins
- Mutation
- Nuclear Proteins
- Peptide Mapping
- Protein Binding
- Yeasts