BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates.

doi:10.1099/0022-1317-78-11-2987

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Article

BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates.

The Journal of general virology - 1 Nov 1997

Khanim F, Dawson C, Meseda C A, Dawson J, Mackett M, Young L S

Abstract excerpt

BHRF 1, a component of the restricted early antigen (EA) complex of the Epstein-Barr virus (EBV) lytic cycle, encodes a 17 kDa putative transmembrane protein with both sequence and functional homology to the Bcl-2 proto-oncogene. To determine whether there was any sequence variation over the BHRF...

Topics

Cloning, Molecular
Conserved Sequence
Herpesvirus 4, Human
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins c-bcl-2
Sequence Analysis
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Transfection
Viral Proteins

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Identifiers

PMID: 9367386
DOI: 10.1099/0022-1317-78-11-2987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9367386-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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