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Article

Identification of genetic events involved in early steps of immortalization of mouse fibroblasts.

Biochimica et biophysica acta - 15 Dec 1994

Kaul S C, Wadhwa R, Sugihara T, Obuchi K, Komatsu Y, Mitsui Y

Abstract excerpt

The spontaneously immortalized early passaged fibroblasts from three different strains of mouse are observed to represent two distinct stages of immortalization. The cells at stage I are characterized by slow growth rate, contact inhibition and requisition of serum factors for their growth and proliferation. Stage II cells are marked by fast, multilayer growth that is independent of serum supplementation in...

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PMID: 7803469
DOI: 10.1016/0304-4165(94)90067-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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