Thermodynamics of denaturation of staphylococcal nuclease mutants: an intermediate state in protein folding.

Abstract excerpt

A valuable approach to understanding the forces that maintain protein structure is to analyze the thermodynamic effects of mutations on protein folding. The folding process is most often described using an energetic model that assumes a two-state transition between the native and denatured states. However, some results obtained using this approach for mutants of the protein staphylococcal nuclease have...

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