Article
One Plus One Makes Three: Triangular Coupling of Correlated Amino Acid Mutations.
The journal of physical chemistry letters - 1 Apr 2021
Werner Martin, Gapsys Vytautas, de Groot Bert L
Abstract excerpt
Correlated mutations have played a pivotal role in the recent success in protein fold prediction. Understanding nonadditive effects of mutations is crucial for altering protein structure, as mutations of multiple residues may change protein stability or binding affinity in a manner unforeseen by the investigation of single mutants. While the couplings between amino acids can be inferred from homologous protein...
Topics
- Amino Acids
- Molecular Dynamics Simulation
- Mutation
- Thermodynamics