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Article

p53 mutations in hepatocellular carcinoma related to oral contraceptive use.

Carcinogenesis - 1 Jan 1996

De Benedetti V M, Welsh J A, Yu M C, Bennett W P

Abstract excerpt

Oral contraceptives (OCs) are implicated in the development of hepatocellular carcinoma (HCC). Mitogenic stimulation may be the primary mechanism of tumorigenesis, but other factors may also contribute. Mutational spectrum analysis can provide insights into pathogenesis, therefore we analyzed the p53 tumor suppressor gene in 10 HCCs from women with a history of OC use. All were non-Asians whose average OC use was...

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Identifiers

PMID: 8565124
DOI: 10.1093/carcin/17.1.145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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