Article
Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.
Oncogene - 17 Nov 2011
Aziz M H, Shen H, Maki C G
Abstract excerpt
Wild-type p53 is a stress-responsive tumor suppressor and potent growth inhibitor. Genotoxic stresses (for example, ionizing and ultraviolet radiation or chemotherapeutic drug treatment) can activate p53, but also induce mutations in the P53 gene, and thus select for p53-mutated cells. Nutlin-3a (Nutlin) is pre-clinical drug that activates p53 in a non-genotoxic manner. Nutlin occupies the p53-binding pocket of...
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