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Article

Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint.

Oncogene - 20 May 2004

D'Assoro Antonino B, Busby Robert, Suino Kelly, Delva Emmanuella, Almodovar-Mercado Gustavo J, Johnson Heidi, Folk Christopher, Farrugia Daniel J, Vasile Vlad, Stivala Franca, Salisbury Jeffrey L

Abstract excerpt

Centrosome amplification plays a key role in the origin of chromosomal instability during cancer development and progression. In this study, breast cancer cell lines with different p53 backgrounds were used to investigate the relationship between genotoxic stress, G(1)/S cell cycle checkpoint integrity, and the development of centrosome amplification. Introduction of DNA damage in the MCF-7 cell line by treatment...

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PMID: 15064746
DOI: 10.1038/sj.onc.1207568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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