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Article

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients.

Nature medicine - 1 Jul 1996

Aas T, Børresen A L, Geisler S, Smith-Sørensen B, Johnsen H, Varhaug J E, Akslen L A, Lønning P E

Abstract excerpt

The mechanisms causing resistance to chemotherapeutic drugs in cancer patients are poorly understood. Recent evidence suggests that different forms of chemotherapy may exert their cytotoxic effects by inducing apoptosis. The tumor suppressor gene P53 has a pivotal role inducing apoptosis in respo...

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Source

Identifiers

PMID: 8673929
DOI: 10.1038/nm0796-811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8673929-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients.PMID 8673929Read ↗

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Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression.Semantic proximity Read ↗

The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cellsSemantic proximity Read ↗

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Semantic proximity Read ↗

Chemotherapy-induced apoptosis in melanoma cells is p53 dependent.Semantic proximity Read ↗

Functional p53 Signaling in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas: Implications for TherapySemantic proximity Read ↗

Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy.Semantic proximity Read ↗

Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells.Semantic proximity Read ↗

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