Article
CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer.
Clinical lung cancer - 1 Sept 2007
Sasaki Hidefumi, Okuda Katsuhiro, Endo Katsuhiko, Kawano Osamu, Yukiue Haruhiro, Yokoyama Tomoki, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) stimulation markedly increases cyclin D1 protein expression. Recently, it has been reported that cyclin D1 expression was increased in EGFR mutant cell lines; however, the expression status of CCND1 in EGFR mutant lung cancer tissues has not been reported. PATIENTS AND METHODS: We have investigated the CCND1 messenger RNA (mRNA) levels and other...
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