Article
Cyclin D1 (CCND1) A870G gene polymorphism modulates smoking-induced lung cancer risk and response to platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2006
Gautschi Oliver, Hugli Barbara, Ziegler Annemarie, Bigosch Colette, Bowers Naomi L, Ratschiller Daniel, Jermann Monika, Stahel Rolf A, Heighway Jim, Betticher Daniel C
Abstract excerpt
PURPOSE: The cyclin D1 (CCND1) A870G gene polymorphism is linked to the outcome in patients with resectable non-small cell lung cancer (NSCLC). Here, we investigated the impact of this polymorphism on smoking-induced cancer risk and clinical outcome in patients with NSCLC stages I-IV. METHODS: CCND1 A870G genotype was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism...
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