HLA‐B27‐Restricted Cytotoxic T Lymphocyte Responses to Arthritogenic Enterobacteria or Self‐Antigens are Dominated by Closely Related TCRBV Gene Segments. A Study in Patients with Reactive Arthritis

Abstract excerpt

Identification of the T-cell receptors (TCR) used by synovial cytotoxic T lymphocytes (CTL) of patients with reactive arthritis (ReA) may be crucial to better understanding the pathogenetic mechanism underlying the HLA-B27 association of spondylarthropathies. The authors, therefore, sequenced 25 TCRB chains from HLA-B27-restricted CD8+ CTL clones and two clonal lines specific for self- or Yersinia enterocolitica...

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