Phenotypic mixing with recombinant haemagglutinin of high cleavability mediates multi-cycle replication of human influenza virus in cell culture.

doi:10.1099/0022-1317-77-1-119

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Article

Phenotypic mixing with recombinant haemagglutinin of high cleavability mediates multi-cycle replication of human influenza virus in cell culture.

The Journal of general virology - 1 Jan 1996

Kaverin N V, Ohuchi M, Ohuchi R, Klenk H D

Abstract excerpt

When CV-1 cells expressing haemagglutinin (HA) of fowl plague virus A/FPV/34/Rostock(H7) (FPV) from an SV40-based recombinant vector were superinfected with the human influenza virus A/FM/1/47(H1N1)(FM1), phenotypically mixed progeny virus was observed. It contained cleaved FPV HA and uncleaved F...

Topics

Animals
Cell Line
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Humans
Influenza A virus
Phenotype
Reassortant Viruses
Trypsin
Virus Replication

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