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Article

The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes

1 Jan 2013

Abstract excerpt

The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can cleave the HA of human seasonal influenza viruses. Consequently, we have investigated the use of human Transmembrane Protease Serine 2 to produce high titre...

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PMID: 23577043
DOI: 10.4172/1747-0862.1000055

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