Article
Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus.
Journal of virology - 1 Sept 2008
Tsurudome Masato, Nishio Machiko, Ito Morihiro, Tanahashi Shunsuke, Kawano Mitsuo, Komada Hiroshi, Ito Yasuhiko
Abstract excerpt
The monoclonal antibody M1-1A, specific for the hemagglutinin-neuraminidase (HN) protein of human parainfluenza type 2 virus (HPIV2), blocks virus-induced cell-cell fusion without affecting the hemagglutinating and neuraminidase activities. F13 is a neutralization escape variant selected with M1-...
Topics
- Animals
- Cell Fusion
- Chlorocebus aethiops
- HN Protein
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Parainfluenza Virus 2, Human
- Recombinant Proteins
- Vero Cells