Article
A single amino acid mutation at position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell death.
Journal of biochemistry - 1 Feb 2011
Takaguchi Masahiro, Takahashi Tadanobu, Hosokawa Chika, Ueyama Hiroo, Fukushima Keijo, Hayakawa Takuya, Itoh Kazuhiko, Ikeda Kiyoshi, Suzuki Takashi
Abstract excerpt
An escape mutant of human parainfluenza virus type 1 (hPIV1), which was selected by serial passage in the presence of a sialidase inhibitor, 4-O-thiocarbamoylmethyl-2-deoxy-2,3-didehydro-N-acetylneur-aminic acid (TCM-Neu5Ac2en), exhibited remarkable syncytium formation and virus-induced cell death in LLC-MK2 cells but no difference in susceptibility for the sialidase inhibitor TCM-Neu5Ac2en from that of wild-type...
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