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Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses

1 May 2000

Abstract excerpt

In order to determine how efficiently the polymerase proteins derived from human and avian influenza A viruses can interact with each other in the context of a mammalian cell, a genetic system that allows the in vivo reconstitution of active ribonucleoproteins was used. The ability to achieve replication of a viral-like reporter RNA in COS-1 cells was examined with heterospecific mixtures of the core proteins...

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PMID: 10769071
DOI: 10.1099/0022-1317-81-5-1283

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