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Article

Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium.

American journal of physiology. Cell physiology - 1 Jul 2010

Schaff U Y, Trott K A, Chase S, Tam K, Johns J L, Carlyon J A, Genetos D C, Walker N J, Simon S I, Borjesson D L

Abstract excerpt

Anaplasma phagocytophilum is an obligate intracellular bacterium that has evolved mechanisms to hijack polymorphonuclear neutrophil (PMN) receptors and signaling pathways to bind, infect, and multiply within the host cell. E-selectin is upregulated during inflammation and is a requisite endothelial receptor that supports PMN capture, rolling, and activation of integrin-mediated arrest. Ligands expressed by PMN...

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Identifiers

PMID: 20392928
DOI: 10.1152/ajpcell.00165.2009
PMCID: PMC2904253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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