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Article

Abnormal cell proliferation and p52/p35-CSK expression in the colons of aging rats.

Experimental gerontology - 1 Jan 2000

Holt P R, Higgins P J, Atillasoy E, Davis P J, Lipkin M

Abstract excerpt

In rodents and in humans, aging is associated with increased gastrointestinal epithelial cell proliferation and an expanded crypt proliferative compartment similar to that seen in the preneoplastic bowel. We have compared the distribution of a series of cytoskeletal antigens that are modified when colonic cancer cells differentiate in vitro in the colon of young (4-7 month) and aging (22-26 month) Fischer 344...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8557097
DOI: 10.1016/0531-5565(95)00011-5

Genes

CSK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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