Clonality Analysis of Immunoglobulin Gene Rearrangement by Next-Generation Sequencing in Endemic Burkitt Lymphoma Suggests Antigen Drive Activation of BCR as Opposed to Sporadic Burkitt Lymphoma.

doi:10.1093/ajcp/aqv011

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Article

Clonality Analysis of Immunoglobulin Gene Rearrangement by Next-Generation Sequencing in Endemic Burkitt Lymphoma Suggests Antigen Drive Activation of BCR as Opposed to Sporadic Burkitt Lymphoma.

American journal of clinical pathology - 1 Jan 2016

Amato Teresa, Abate Francesco, Piccaluga Pierpaolo, Iacono Michele, Fallerini Chiara, Renieri Alessandra, De Falco Giulia, Ambrosio Maria Raffaella, Mourmouras Vaselious, Ogwang Martin, Calbi Valeria, Rabadan Roul, Hummel Michael, Pileri Stefano, Leoncini Lorenzo, Bellan Cristiana

Abstract excerpt

OBJECTIVES: Recent studies using next-generation sequencing (NGS) analysis disclosed the importance of the intrinsic activation of the B-cell receptor (BCR) pathway in the pathogenesis of sporadic Burkitt lymphoma (sBL) due to mutations of TCF3/ID3 genes. Since no definitive data are available on the genetic landscape of endemic Burkitt (eBL), we first assessed the mutation frequency of TCF3/ID3 in eBL compared...

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PMID: 26712879
DOI: 10.1093/ajcp/aqv011
PMCID: PMC4778259

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BCR
TCF3

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