Article
Evidence of linkage between susceptibility to multiple sclerosis and HLA-class II loci in Italian multiplex families.
European journal of human genetics : EJHG - 1 Jan 1995
Eoli M, Pandolfo M, Amoroso A, Salmaggi A, Zaffaroni M, Gasparini P, DiDonato S, Milanese C, Zeviani M
Abstract excerpt
To verify whether multiallelic polymorphisms belonging to HLA class II genes are linked to multiple sclerosis (MS) in the Italian population, we studied 28 multiplex MS families originating from different areas of Italy. Allelic characterization was carried out by analysis of RFLPs and oligonucle...
Topics
- Alleles
- Chi-Square Distribution
- Female
- Genes, MHC Class II
- Genes, Recessive
- Genetic Linkage
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Italy
- Lod Score
- Male
- Molecular Epidemiology
- Multiple Sclerosis
- Pedigree
- Statistics, Nonparametric