Article
Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas.
Cancer - 15 Jul 1996
Tsuzuki T, Tsunoda S, Sakaki T, Konishi N, Hiasa Y, Nakamura M
Abstract excerpt
BACKGROUND: Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, p16(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G1-S checkpoint. METHODS: Alterations of the RB, p53, p16(CDKN2), and p1...
Topics
- Astrocytoma
- Blotting, Western
- Brain Neoplasms
- Carrier Proteins
- Cell Cycle Proteins
- Codon
- Codon, Terminator
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Enzyme Inhibitors
- Exons
- G1 Phase
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma
- Genes, Tumor Suppressor
- Genes, cdc
- Genes, p53