Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas.

Cancer - 15 Jul 1996

Tsuzuki T, Tsunoda S, Sakaki T, Konishi N, Hiasa Y, Nakamura M

Abstract excerpt

BACKGROUND: Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, p16(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G1-S checkpoint. METHODS: Alterations of the RB, p53, p16(CDKN2), and p15 genes in human astrocytomas were screened by single strand conformation polymorphism analysis of polymerase chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Carrier Proteins
Share to Codon

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Expression Regulation, Neoplastic

Share to Genes, p53

Share to Genes, Tumor Suppressor

Source

Identifiers

PMID: 8674005
DOI: 10.1002/(SICI)1097-0142(19960715)78:2<287::AID-CNCR15>3.0.CO;2-S

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas.PMID 8674005Read ↗

A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations.Semantic proximity Read ↗

Alterations in the tumor suppressor genes p53, RB, p16/MTS1, and p15/MTS2 in human pancreatic cancer and hepatoma cell lines.Semantic proximity Read ↗

Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course.Semantic proximity Read ↗

Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma.Semantic proximity Read ↗

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.Semantic proximity Read ↗

Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas.Semantic proximity Read ↗

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.Semantic proximity Read ↗

Alterations of the p53 and pRB pathways in human astrocytoma.Semantic proximity Read ↗

The retinoblastoma gene is involved in malignant progression of astrocytomasSemantic proximity Read ↗

Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas.Semantic proximity Read ↗

Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas.Semantic proximity Read ↗

Mutations of the p16 gene in gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.