Article
Translational control by delayed RNA folding: identification of the kinetic trap.
RNA (New York, N.Y.) - 1 Mar 2001
van Meerten D, Girard G, van Duin J
Abstract excerpt
The maturation or A-protein gene of single-stranded RNA phage MS2 is preceded by a 130-nt long untranslated leader. When MS2 RNA folding is at equilibrium, the gene is untranslatable because the leader adopts a well-defined cloverleaf structure in which the Shine-Dalgarno (SD) sequence of the maturation gene is taken up in long-distance base pairing with an upstream complementary sequence (UCS). Synthesis of the...
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