Article
Coevolution of RNA helix stability and Shine-Dalgarno complementarity in a translational start region.
Molecular microbiology - 1 Jan 1995
Olsthoorn R C, Zoog S, van Duin J
Abstract excerpt
The initiation region of the coat-protein gene of RNA bacteriophage MS2 adopts a well-defined hairpin structure with the start codon occupying the loop position, while the Shine-Dalgarno (SD) sequence is part of the stem. In a previous study, we introduced mutations in this hairpin that changed its thermodynamic stability. The resulting phages evolved to regain the wild-type stability by second-site compensatory...
Topics
- Base Sequence
- Binding Sites
- Biological Evolution
- Capsid
- Capsid Proteins
- Codon
- Levivirus
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Nucleic Acid Conformation
- Point Mutation