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Article

Coevolution of RNA helix stability and Shine-Dalgarno complementarity in a translational start region.

Molecular microbiology - 1 Jan 1995

Olsthoorn R C, Zoog S, van Duin J

Abstract excerpt

The initiation region of the coat-protein gene of RNA bacteriophage MS2 adopts a well-defined hairpin structure with the start codon occupying the loop position, while the Shine-Dalgarno (SD) sequence is part of the stem. In a previous study, we introduced mutations in this hairpin that changed its thermodynamic stability. The resulting phages evolved to regain the wild-type stability by second-site compensatory...

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PMID: 7746154
DOI: 10.1111/j.1365-2958.1995.tb02247.x

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