Article
The induction/loss of the oxidant-resistant phenotype of Chinese hamster ovary (CHO) cell variants does not correlate with sensitivity to DNA single strand breakage by hydrogen peroxide.
Biochemical pharmacology - 1 Nov 1994
Sestili P, Cattabeni F, Cantoni O
Abstract excerpt
Hydrogen peroxide resistant variants of Chinese hamster ovary (CHO) cells characterized by different levels of resistance to growth inhibition induced by the oxidant displayed a decreased susceptibility to the induction of DNA single strand breakage by hydrogen peroxide. Resistance to DNA damage,...
Topics
- Animals
- CHO Cells
- Cell Division
- Cricetinae
- DNA Damage
- DNA, Single-Stranded
- Dose-Response Relationship, Drug
- Drug Resistance
- Electrophoresis, Gel, Pulsed-Field
- Hydrogen Peroxide
- Phenotype