Transcription regulation in NIH3T3 cell clones resistant to diethylmaleate-induced oxidative stress and apoptosis.

doi:10.1089/ars.2006.8.365

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Article

Transcription regulation in NIH3T3 cell clones resistant to diethylmaleate-induced oxidative stress and apoptosis.

Antioxidants & redox signaling - 1 Jan 2000

Faraonio Raffaella, Vergara Paola, Marzo Domenico Di, Napolitano Maria, Russo Tommaso, Cimino Filiberto

Abstract excerpt

To investigate the molecular mechanisms underlying the induction of cell resistance to oxidative stress, NIH3T3 cell clones (NIH-DEM clones) were isolated and selected for their ability to survive the exposure to diethylmaleate (DEM), a glutathione-depleting agent. The oxidative stress-resistant phenotype of these clones is stable for at least 1 month in the absence of DEM, and includes the resistance also to...

Topics

Animals
Apoptosis
Gene Expression Regulation
Glutathione Transferase
Maleates
Mice
NIH 3T3 Cells
Oxidants
Oxidative Stress
Phenotype
Plasmids
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 16677083
DOI: 10.1089/ars.2006.8.365

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