Article
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype.
Biochemical pharmacology - 9 Jun 1993
Cantoni O, Guidarelli A, Sestili P, Mannello F, Gazzanelli G, Cattabeni F
Abstract excerpt
Hydrogen peroxide (H2O2)-resistant sublines of Chinese hamster ovary (CHO) cells were isolated by in vitro exposure to the oxidant (treatment for 1 hr followed by 3 days of growth in peroxide-free medium). Stepwise increase in low level H2O2 concentrations produced variants which were progressive...
Topics
- Animals
- CHO Cells
- Catalase
- Cell Division
- Cell Line
- Cricetinae
- Cricetulus
- Dose-Response Relationship, Drug
- Drug Resistance
- Hydrogen Peroxide
- Phenotype
- Proteins