Phosphoribosyl diphosphate synthetase-independent NAD de novo synthesis in Escherichia coli: a new phenotype of phosphate regulon mutants.

Abstract excerpt

Phosphoribosyl diphosphate-lacking (delta prs) mutant strains of Escherichia coli require NAD, guanosine, uridine, histidine, and tryptophan for growth. NAD is required by phosphoribosyl diphosphate-lacking mutants because of lack of one of the substrates for the quinolinate phosphoribosyltransfe...

Topics

• Escherichia coli
• Mutation
• NAD
• Nicotinamide Mononucleotide
• Phenotype
• Phosphoribosyl Pyrophosphate
• Ribose-Phosphate Pyrophosphokinase