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Article

Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica.

Microbiology (Reading, England) - 1 Mar 2010

Koenigsknecht Mark J, Fenlon Luke A, Downs Diana M

Abstract excerpt

Phosphoribosylamine (PRA) is the first intermediate in the common purine/thiamine biosynthetic pathway and is primarily synthesized by the product of the purF gene, glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (E.C. 2.4.2.14). Past genetic and biochemical studies have shown that multiple mechanisms for the synthesis of PRA independent of PurF are present in Salmonella enterica. Here, we describe...

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Identifiers

PMID: 19959576
DOI: 10.1099/mic.0.033050-0
PMCID: PMC2889433

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Source receipt: pubmed, retrieved 7 Sept 2026.

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