Article
Mutator phenotype in a subset of chronic lymphocytic leukemia.
Blood - 1 Jan 1996
Gartenhaus R, Johns M M, Wang P, Rai K, Sidransky D
Abstract excerpt
The replication error phenotype (RER+), characterized by widespread microsatellite instability, is an important feature of tumors from patients with hereditary nonpolyposis colorectal carcinoma (HNPCC). This widespread instability affects repeat tracts of all lengths and is usually attributed to mutations of critical mismatch repair genes. Recently, several reports described occasional microsatellite alterations...
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