Article
Inhibition of human glioblastoma cell growth by WAF1/Cip1 can be attenuated by mutant p53.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1995
Jung J M, Li H, Kobayashi T, Kyritsis A P, Langford L A, Bruner J M, Levin V A, Zhang W
Abstract excerpt
The WAF1/Cip1 protein is an important regulator at the G1 checkpoint in the cell cycle. The WAF1/Cip1 protein binds to the cyclin-dependent kinase complexes and inhibits the kinase activity that is required for cell cycle progression. We investigated the expression of WAF1/Cip1 protein in 14 glioblastoma cell lines and found that WAF1/Cip1 expression was detectable in many of the cell lines, even when mutant p53...
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