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Article

Preferred usage of specific immunoglobulin gene segments in chronic lymphocytic leukaemia cells of three HLA-identical sisters.

British journal of haematology - 1 Dec 1995

Hakim I, Amariglio N, Brok-Simoni F, Berkowitz M, Rosner E, Kneller A, Hulu N, Ramot B, Ben-Bassat I, Silverman G J

Abstract excerpt

We report three family members, including a set of identical twins, who developed CD5 positive B-CLL. The patients are female Ashkenazi Jews sharing an identical HLA phenotype. Two of the HLA loci (B35 and Cw4) were common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL. The rearranged immunoglobulin genes of the malignant cells of all three patients were found to...

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Identifiers

PMID: 8547138
DOI: 10.1111/j.1365-2141.1995.tb05409.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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