Article
Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels.
Neurobiology of disease - 1 Nov 2005
Köhler Christoph, Ebert Ulrich, Baumann Karlheinz, Schröder Hannsjörg
Abstract excerpt
Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein. We studied the phenotype of three different strains of gene-targeted mice which express the amyloid precursor protein at endogenous levels. Only further crossing with...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Apolipoproteins E
- Brain
- Cathepsin D
- Cell Line
- Chimera
- Cholinergic Fibers
- Disease Models, Animal
- Female