Formation of beta-amyloid protein deposits in brains of transgenic mice.

doi:10.1038/352239a0

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Article

Formation of beta-amyloid protein deposits in brains of transgenic mice.

Nature - 18 Jul 1991

Quon D, Wang Y, Catalano R, Scardina J M, Murakami K, Cordell B

Abstract excerpt

Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is derived from the beta-amyloid precursor protein (beta-APP) which is expressed in several different isoforms. Th...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Base Sequence
Blotting, Western
Brain
Female
Genotype
Humans
Immunoenzyme Techniques
Male
Mice
Mice, Transgenic
Molecular Sequence Data
Oligonucleotide Probes
Protein Precursors

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