Article
Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1996
Khan I A, Matsuura T, Fonseka S, Kasper L H
Abstract excerpt
Production of nitric oxide (NO) by macrophages is important for the killing of intracellular pathogens. IFN-gamma and LPS stimulate NO production by transcriptional up-regulation of inducible nitric oxide synthetase (iNOS). In the present study we used mice with a targeted disruption of the IFN r...
Topics
- Animals
- Arginine
- CD4-Positive T-Lymphocytes
- DNA-Binding Proteins
- Female
- Genetic Predisposition to Disease
- Immunologic Factors
- Interferon Regulatory Factor-1
- Interferon-gamma
- Interleukin-10
- Interleukin-12
- Lymphocyte Activation
- Lymphocyte Depletion
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nitric Oxide
- Nitric Oxide Synthase