Article
TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii.
Parasite immunology - 1 Jul 1999
Liesenfeld O, Kang H, Park D, Nguyen T A, Parkhe C V, Watanabe H, Abo T, Sher A, Remington J S, Suzuki Y
Abstract excerpt
We previously reported that genetic susceptibility of mice to peroral infection with T. gondii is associated with CD4+ T cell-dependent, interferon (IFN)-gamma-mediated necrosis of their small intestine. We examined the role of tumour necrosis factor (TNF)-alpha and nitric oxide (NO), in addition to IFN-gamma. At 7 days after infection, a marked increase in CD4+ T cells was observed in lamina propria mononuclear...
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