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Article

Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

Science (New York, N.Y.) - 18 Mar 1994

Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, Le J, Koh S I, Kimura T, Green S J

Abstract excerpt

Production of nitric oxide (NO) by macrophages is important for the killing of intracellular infectious agents. Interferon (IFN)-gamma and lipopolysaccharide stimulate NO production by transcriptionally up-regulating the inducible NO synthase (iNOS). Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene (IRF-1-/- mice) produced little or no NO and synthesized barely...

Topics

Amino Acid Oxidoreductases
Animals
Base Sequence
DNA-Binding Proteins
Enzyme Induction
Interferon Regulatory Factor-1
Interferons
Lipopolysaccharides
Macrophage Activation
Macrophages, Peritoneal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Inbred DBA

Molecular Sequence Data

Mutation

Mycobacterium bovis

Nitric Oxide

Nitric Oxide Synthase

Source

Identifiers

PMID: 7510419
DOI: 10.1126/science.7510419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7510419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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