Article
Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.
Cancer research - 1 Sept 1996
Foley J, Wysolmerski J J, Broadus A E, Philbrick W M
Abstract excerpt
Parathyroid hormone-related protein (PTHrP) is a normal secretory product of a variety of squamous epithelia, including epidermal keratinocytes. Only a subset of squamous carcinomas, however, express the gene at levels sufficient to cause humoral hypercalcemia. In the present study, comparison of...
Topics
- Adenovirus E1B Proteins
- Carcinoma, Squamous Cell
- Gene Expression
- Genes, Reporter
- Genes, p53
- Humans
- Isomerism
- Keratinocytes
- Mutation
- Parathyroid Hormone-Related Protein
- Promoter Regions, Genetic
- Protein Biosynthesis
- Proteins
- RNA, Messenger
- TATA Box
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53