Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.

Cancer research - 1 Sept 1996

Foley J, Wysolmerski J J, Broadus A E, Philbrick W M

Abstract excerpt

Parathyroid hormone-related protein (PTHrP) is a normal secretory product of a variety of squamous epithelia, including epidermal keratinocytes. Only a subset of squamous carcinomas, however, express the gene at levels sufficient to cause humoral hypercalcemia. In the present study, comparison of PTHrP expression levels with p53 functional status in a series of squamous carcinoma lines has revealed an association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression
Share to Genes, p53
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Proteins

Share to RNA, Messenger

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8752179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.PMID 8752179Read ↗

Activation of PTHrP gene expression in squamous carcinoma cell lines by mutant isoforms of the tumor suppressor p53.Semantic proximity Read ↗

Clonal variation of p53 expression and proliferative phenotype in A253 squamous carcinoma cells.Semantic proximity Read ↗

Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

Neoplastic transformation of normal rat embryo fibroblasts by a mutated p53 and an activated ras oncogene induces parathyroid hormone-related peptide gene expression and causes hypercalcemia in nude mice.Semantic proximity Read ↗

Functional characterization in vivo of mutant p53 molecules derived from squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.Semantic proximity Read ↗

The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation.Semantic proximity Read ↗

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.Semantic proximity Read ↗

The H19 TATA-less promoter is efficiently repressed by wild-type tumor suppressor gene product p53Semantic proximity Read ↗

Absence of p53 point mutations in parathyroid adenoma and carcinoma.Semantic proximity Read ↗

Differential effects of p53 mutants on the growth of human bronchial epithelial cells.Semantic proximity Read ↗

Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.