Parathyroid Hormone-Related Protein: An Update

doi:10.1210/jc.2012-2142

Article

Parathyroid Hormone-Related Protein: An Update

29 Jun 2012

Abstract excerpt

PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago. In the intervening years, we have learned that PTHrP and PTH are encoded by related genes that are part of a larger "PTH gene family." This evolutionary relationship permits them to bind to the same type 1 PTH/PTHrP receptor, which explains why humoral hypercalcemia of malignancy resembles hyperparathyroidism. This review will outline...

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