Article
Low frequency of p53 and ras mutations in bile of patients with hepato-biliary disease: a prospective study in more than 100 patients.
European journal of clinical investigation - 1 Mar 2001
Müller P, Ostwald C, Püschel K, Brinkmann B, Plath F, Kröger J, Barten M, Nizze H, Schareck W D, Hauenstein K, Liebe S, Löhr J M
Abstract excerpt
The diagnosis of biliary disease, namely malignant disorders, is frequently hampered by the inconclusive cytology. We investigated prospectively the frequency of molecular changes in p53 and ras compared with cytology in patients with primary or secondary hepato-biliary disease. We investigated 118 consecutive patients, aged 24-89 with the following clinical diagnoses: choledocho/cholecystolithiasis (28),...
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