Article
Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Gastroenterology - 1 May 1996
Villanueva A, Reyes G, Cuatrecasas M, Martínez A, Erill N, Lerma E, Farré A, Lluís F, Capellá G
Abstract excerpt
BACKGROUND & AIMS: Mutations at codon 12 of the K-ras gene are present in 65%-100% of carcinomas of human exocrine pancreas and could be used as a potential tumor marker at the tissue level. The purpose of this study was to assess, in large series of patients, the utility of K-ras mutation analys...
Topics
- Aged
- Base Sequence
- Biopsy, Needle
- Female
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pancreas
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Predictive Value of Tests
- Retrospective Studies
- Sensitivity and Specificity