Article
Phenotypic characterization of two cell populations involved in the acquisition of suppressor activity by cultured spleen cells from Mycobacterium lepraemurium-infected mice.
Clinical and experimental immunology - 1 Dec 1995
Gosselin D, Turcotte R, Lemieux S
Abstract excerpt
The impairment of cellular immunity in mice infected with Mycobacterium lepraemurium was shown to correlate with the development of suppressor cells. We have previously reported that before suppressor activity is detectable in freshly harvested cell suspensions, suppressor cell precursors accumulate in the spleen of infected mice. Upon overnight culture in the presence of a regulatory cell subset, these precursor...
Topics
- Animals
- Cells, Cultured
- Female
- G(M1) Ganglioside
- Killer Cells, Natural
- Macrophage-1 Antigen
- Mice
- Mice, Inbred C3H
- Mycobacterium Infections
- Mycobacterium lepraemurium
- Phenotype
- Receptors, Antigen, T-Cell, gamma-delta
- Spleen
- T-Lymphocytes, Regulatory