Article
Proliferation of natural suppressor cells in long-term cultures of spleen cells from normal adult mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1991
Yoshida T, Norihisa Y, Habu S, Kobayashi N, Takei M, Kanehira N, Shimamura T
Abstract excerpt
Natural suppressor cells were induced by culturing spleen cells from normal adult mice for 2 to 3 wk. The suppressor cells were large in size, nonadherent and nonspecifically suppressed the plaque-forming cells response of fresh spleen cells to SRBC in vitro. The suppressive activity of the cells was not affected by treatment with indomethacin or anti-Thy-1, anti-Ig, anti-Ia, or anti-asialoGM1 plus complement....
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