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Article

Proliferation of natural suppressor cells in long-term cultures of spleen cells from normal adult mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1991

Yoshida T, Norihisa Y, Habu S, Kobayashi N, Takei M, Kanehira N, Shimamura T

Abstract excerpt

Natural suppressor cells were induced by culturing spleen cells from normal adult mice for 2 to 3 wk. The suppressor cells were large in size, nonadherent and nonspecifically suppressed the plaque-forming cells response of fresh spleen cells to SRBC in vitro. The suppressive activity of the cells was not affected by treatment with indomethacin or anti-Thy-1, anti-Ig, anti-Ia, or anti-asialoGM1 plus complement....

Topics

Animals
Cells, Cultured
Cytotoxicity, Immunologic
Indomethacin
Lymphocyte Activation
Male
Mice
Mice, Inbred C3H
Phenotype
Spleen
T-Lymphocytes, Regulatory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1836480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1836480-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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