Soybean agglutinin-positive natural suppressor cells in mouse bone marrow inhibit interleukin 2 production and utilization in mixed lymphocyte reactions.

Abstract excerpt

Although natural suppressor (NS) cells resident in bone marrow (BM) have been the subject of intensive study, the exact nature and mode of action of these potentially important immunoregulatory cells are still uncertain. Here we show that NS cells with potent inhibitory effects on mixed lymphocyte reactions (MLRs) can be isolated from BM of normal adult mice by agglutination with the plant lectin soybean...

Topics

• Agglutination
• Animals
• Bone Marrow
• Interleukin-2
• Lectins
• Lymphocyte Culture Test, Mixed
• Mice
• Mice, Inbred CBA
• Mice, Inbred DBA
• Phenotype
• Plant Lectins